Aminocoumarins are found to be present in many natural products, pharmaceuticals, and
organic materials. These derivatives demonstrate numerous biological activities including …

Toll-like receptors (TLRs) are members of a large family of evolutionarily conserved pattern
recognition receptors (PRRs), which serve as key components of the innate immune system …

Both pyrazole and coumarin moiety are important scaffolds for their natural occurrences as
well as a broad spectrum of pharmaceutical properties. When coumarin fuses with pyrazole …

To discover new Werner (WRN) helicase inhibitors, a series of N-aryl-2-trifluoromethyl-
quinazoline-4-amine derivatives were designed and synthesized through a structural …

The oxidative C (sp3)–H intramolecular imination of hydroxycoumarin enol-Ugi adduct
derivatives affords selectively diversely substituted imidazolocoumarins in one pot. The …

A metal-free, efficient and easy-to-hand protocol for the synthesis of 2-
perfluoroalkylquinazolins has been achieved by Eosin B catalyzed radical cascade …

Toll-like receptors (TLRs) are components of innate immunity that play a crucial role in
several diseases, including chronic inflammatory and infectious diseases, autoimmune …

The use of large molecules for immunotherapy has led to exciting developments in cancer
treatment, such as the development of PD-1/PD-L1 antibodies. However, small molecule …

Two targeted sets of novel 1, 5-diaryl-1 H-imidazole-4-carboxylic acids 10 and
carbohydrazides 11 were designed and synthesized from their corresponding ester …

Brønsted acid‐mediated intramolecular cyclization of 2‐amidoazulene derivatives, prepared
by the reaction of 1‐cyano‐2‐aminoazulene derivatives with perfluoroalkyl acid anhydrides …