Molecular targeted therapy: a new avenue in glioblastoma treatment
O El Atat, R Naser, M Abdelkhalek… - Oncology …, 2022 - spandidos-publications.com
Glioblastoma, also referred to as glioblastoma multiforme (GBM), is grade IV astrocytoma
characterized by being fast-growing and the most aggressive brain tumor. In adults, it is the …
characterized by being fast-growing and the most aggressive brain tumor. In adults, it is the …
Synthesis and significance of arachidonic acid, a substrate for cyclooxygenases, lipoxygenases, and cytochrome P450 pathways in the tumorigenesis of glioblastoma …
Simple Summary Glioblastoma multiforme is a brain tumor with a very unfavorable
prognosis, where the vast majority of patients do not survive a year after diagnosis. One line …
prognosis, where the vast majority of patients do not survive a year after diagnosis. One line …
Lysophosphatidic acid signaling in cancer cells: what makes LPA so special?
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …
Lysophosphatidic acid receptor antagonists and cancer: the current trends, clinical implications, and trials
Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane
phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled …
phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled …
Integration of an LPAR1 antagonist into liposomes enhances their internalization and tumor accumulation in an animal model of human metastatic breast cancer
Lysophosphatidic acid receptor 1 (LPAR1) is elevated in breast cancer. The deregulation of
LPAR1, including the function and level of expression, is linked to cancer initiation …
LPAR1, including the function and level of expression, is linked to cancer initiation …
Protein kinase C (PKC) isozymes as diagnostic and prognostic biomarkers and therapeutic targets for cancer
T Kawano, J Inokuchi, M Eto, M Murata, JH Kang - Cancers, 2022 - mdpi.com
Simple Summary Protein kinase C (PKC) isozymes play key roles in the proliferation,
differentiation, survival, migration, invasion, apoptosis, and anticancer drug resistance of …
differentiation, survival, migration, invasion, apoptosis, and anticancer drug resistance of …
[HTML][HTML] Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis
S Li, Z Xu, Y Wang, L Chen, X Wang, Y Zhou, D Lei… - Genes & …, 2024 - Elsevier
Atherosclerotic cardiovascular disease and its complications are a high-incidence disease
worldwide. Numerous studies have shown that blood flow shear has a huge impact on the …
worldwide. Numerous studies have shown that blood flow shear has a huge impact on the …
The interplay between estrogen receptor beta and protein kinase C, a crucial collaboration for medulloblastoma cell proliferation and invasion
R Hernández-Rojas, C Jiménez-Arellano… - Cellular …, 2022 - Elsevier
Medulloblastoma (MB) is the most common and aggressive pediatric intracranial tumor.
Estrogen receptor β (ERβ) expression correlates with MB development and its …
Estrogen receptor β (ERβ) expression correlates with MB development and its …
Effects of progesterone on T-type-Ca2+-channel expression in Purkinje cells
A Eickhoff, J Tjaden, S Stahlke, M Vorgerd… - Neural Regeneration …, 2022 - journals.lww.com
Plasticity of cerebellar Purkinje cells (PC) is influenced by progesterone via the classical
progesterone receptors PR-A and PR-B by stimulating dendritogenesis, spinogenesis, and …
progesterone receptors PR-A and PR-B by stimulating dendritogenesis, spinogenesis, and …
MicroRNA-429 overexpression overcomes imatinib resistance of glioma cells by negatively regulating lysophosphatidic acid receptor 1
J **a, Z Peng, M Zhang, Q Liao, C Liu… - Neurological …, 2024 - Taylor & Francis
Background Glioma is one of the most aggressive and lethal malignancies in central
nervous system. It has been reported that miR-429 is declined in glioma and functions as a …
nervous system. It has been reported that miR-429 is declined in glioma and functions as a …