Heme has a critical role in the chemical framework of the cell as an essential protein cofactor
and signaling molecule that controls diverse processes and molecular interactions. Using a …

Peptide-brush polymers generated by graft-through living polymerization of peptide-
modified monomers exhibit high proteolytic stability, therapeutic efficacy, and potential as …

Abstract Inhibition of Insulin-Regulated Aminopeptidase is being actively explored for the
treatment of several human diseases and several classes of inhibitors have been developed …

SPACA6 is a sperm-expressed surface protein that is critical for gamete fusion during
mammalian sexual reproduction. Despite this fundamental role, little is known about how …

Lactate levels in humans reveal intensity and duration of exertion and provide a critical
readout for the severity of life-threatening illnesses such as pediatric sepsis. Using the …

A myriad of biological processes are facilitated by ligand–receptor interactions. The low
affinities of these interactions are typically enhanced by multivalent engagements to promote …

Carbohydrate recognition is imperative for the induction of sperm acrosomal exocytosis
(AE), an essential phenomenon in mammalian fertilization. In mouse sperm, polynorbornene …

The complement system and neutrophils constitute the two main pillars of the host innate
immune defense against infection by bacterial pathogens. Here, we identify T-Mac, a novel …

Nucleic acids (RNA and DNA) play crucial roles in all living organisms and find wide utility in
clinical settings. The convergence of rationally designed nucleic acid multistranded …

Constructing a comprehensive understanding of macromolecular behavior from a set of
correlated small angle scattering (SAS) data is aided by tools that analyze all scattering …