The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …

Obstructive sleep apnea syndrome (OSAS) is characterized by intermittent hypoxia (IH)
during sleep due to recurrent upper airway obstruction. The derived oxidative stress (OS) …

There is emerging evidence that obstructive sleep apnea (OSA) is a risk factor for preclinical
Alzheimer's disease (AD). An American Thoracic Society workshop was convened that …

Adequate oxygen supply is essential for the human brain to meet its high energy demands.
Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation …

Sleep-disordered breathing is highly prevalent in the elderly population. Obstructive sleep
apnea (OSA) represents the most common sleep disorder among the adult and elderly …

Background Obstructive sleep apnea (OSA) increases risk for cognitive decline and
Alzheimer's disease (AD). While the underlying mechanisms remain unclear, hypoxemia …

Chronic intermittent hypoxia (CIH) and chronic sleep fragmentation (CSF) are two cardinal
pathological features of obstructive sleep apnea (OSA). Dietary obesity is a crucial risk …