The pulmonary route has long been used for drug administration for both local and systemic
treatment. It possesses several advantages, which can be categorized into physiological, ie …

This review covers recent developments in the area of particle engineering via spray drying.
The last decade has seen a shift from empirical formulation efforts to an engineering …

Theoretical and experimental investigations of the particle formation process during spray
drying are presented. A novel experimental method allows observation of individual, free …

With the rapidly growing popularity and sophistication of inhalation therapy, there is an
increasing demand for tailor-made inhalable drug particles capable of affording the most …

Despite the wide use of antibiotics, bacterial infection is still one of the leading causes of
hospitalization and mortality. The clinical failure of antibiotic therapy is linked with low …

Dry powder inhaler (DPI) products have traditionally comprised a simple formulation of
micronised drug mixed with a carrier excipient, typically lactose monohydrate. The presence …

Leucine is a promising excipient with several applications in the development of inhalable
spray-dried powder of high-and low-dose drugs. The addition of leucine has exhibited …

An aerosol flow reactor was used for the first time for high-throughput, high yield synthesis of
spherical lignin particles with given inherent hydrophilicity, depending on the precursor …

Spray-drying is an inherently continuous and well-established industrial drying process. It
can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting in both …

For inhalation drug delivery, amorphous powder formulations offer the benefits of increased
bioavailability for poorly soluble drugs, improved biochemical stability for biologics, and …