Multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy. P-
glycoprotein (P-gp), a promiscuous drug efflux pump, has been extensively studied for its …

ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of integral
membrane proteins that are responsible for the ATP-powered translocation of many …

▪ Abstract The ATP-binding cassette (ABC) transporters are a family of large proteins in
membranes and are able to transport a variety of compounds through membranes against …

Multidrug transporters of the ABC family facilitate the export of diverse cytotoxic drugs across
cell membranes. This is clinically relevant, as tumour cells may become resistant to agents …

ABCB1 (MDR1) is one of many ubiquitous adenosine triphosphate (ATP)-binding cassette
(ABC) genes present in all kingdoms of life that is responsible for cellular homeostasis [1–3] …

The acquisition of multidrug resistance is a serious impediment to improved healthcare.
Multidrug resistance is most frequently due to active transporters that pump a broad …

ABC transporters mediate active translocation of a diverse range of molecules across all cell
membranes. They comprise two nucleotide-binding domains (NBDs) and two …

ATP-binding cassette (ABC) transporters are ubiquitous membrane proteins that couple the
transport of diverse substrates across cellular membranes to the hydrolysis of ATP. The …

Mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator
(CFTR) epithelial anion channel cause cystic fibrosis (CF). The multidomain integral …

Iron-sulfur (Fe/S) proteins are involved in a wide variety of cellular processes such as
enzymatic reactions, respiration, cofactor biosynthesis, ribosome biogenesis, regulation of …