Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …

Physical activity has received substantial research attention due to its beneficial impact on
cognition in ageing, particularly via the action of brain-derived neurotrophic factor (BDNF). It …

Nerve growth factor (NGF) was discovered in the early 1950s due to its trophic (survival-and
growth-promoting) effects on sensory and sympathetic neurons (Levi-Montalcini and …

Abstract Changes in the levels and activities of neurotrophic factors, such as brain-derived
neurotrophic factor (BDNF), have been described in a number of neurodegenerative …

Interest in BDNF as an activity-dependent modulator of neuronal structure and function in
the adult brain has intensified in recent years. Localization of BDNF-TrkB to glutamate …

We have previously shown that voluntary exercise produces enhanced neurogenesis and
long-term potentiation (LTP) in the dentate gyrus (DG) of mice in vitro. In the present …

Depression is a well-known disabling mental illness characterized by sadness, loss of
interest in activities, and decreased energy. The symptoms of depression are usually …

Electrical signaling in neurons is based on the operation of plasmalemmal ion pumps and
carriers that establish transmembrane ion gradients, and on the operation of ion channels …

Diverse brain insults, including traumatic brain injury, stroke, infections, tumors,
neurodegenerative diseases, and prolonged acute symptomatic seizures, such as complex …

Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …