Historically, the term 'keratin'stood for all of the proteins extracted from skin modifications,
such as horns, claws and hooves. Subsequently, it was realized that this keratin is actually a …

Background/aims: The influence of mechanical forces on skin has been examined since
1861 when Langer first reported the existence of lines of tension in cadaver skin. Internal …

In this paper we present keratin expression data that lend strong support to a model of
corneal epithelial maturation in which the stem cells are located in the limbus, the …

Epithelial-mesenchymal interactions control epidermal growth and differentiation, but little is
known about the mechanisms of this interaction. We have examined the effects of human …

The protooncogene c-myc regulates cell growth, differentiation, and apoptosis, and its
aberrant expression is frequently observed in human cancer. However, the consequences of …

During epidermal cell cornification, the deposition of a layer of covalently cross-linked
protein on the cytoplasmic face of the plasma membrane forms the cell envelope. We have …

Keratinocytes isolated from human epidermis and subsequently cultured may form clones if
they are 11 micron or less in diameter but are irreversibly committed to further enlargement …

Nonmelanoma skin cancer is the leading cause of cancer in the United States. Cutaneous
squamous cell carcinoma is second only to basal cell carcinoma in prevalence and its …

The epidermis is a dynamic, continually renewing structure that provides the organism with a
life-sustaining interface with the environment. The major cell type of the epidermis, the …

The asymmetric unit membrane (AUM) forms the apical plaques of mammalian urothelium
and is believed to play a role in strengthening the urothelial apical surface thus preventing …