The gastrointestinal tract is innervated by several distinct populations of neurons, whose cell
bodies either reside within (intrinsic) or outside (extrinsic) the gastrointestinal wall. Normally …

Intrinsic primary afferent neurons (IPANs) of the enteric nervous system are quite different
from all other peripheral neurons. The IPANs are transducers of physiological stimuli …

Free radical-induced cellular stress contributes to cancer during chronic inflammation. Here,
we investigated mechanisms of p53 activation by the free radical, NO. NO from donor drugs …

Inflammatory bowel diseases (IBD) encompass at least two forms of intestinal inflammation:
Crohn's disease and ulcerative colitis (UC). Both conditions are chronic and inflammatory …

Vanillic acid, an oxidized form of vanillin, is a benzoic acid derivative used as a flavoring
agent. The objective of this study was to determine whether vanillic acid has beneficial …

The influence of the immune system on gastrointestinal (GI) function has long been
recognized. The work has focused mainly on the effect of overt inflammation on GI motility …

Decades of work in animal models have demonstrated that the enteric nervous system
(ENS) plays a key role in controlling gut functions. Recent advances made it possible to …

Neuroplastic changes in the enteric nervous system (ENS) may be observed in
physiological states, such as development and aging, or occur as a consequence of different …

Chronic abdominal pain accompanying intestinal inflammation emerges from the
hyperresponsiveness of neuronal, immune and endocrine signaling pathways within the …

Inflammation of the bowel causes structural and functional changes to the enteric nervous
system (ENS). While morphological alterations to the ENS are evident in some inflammatory …