The blood–brain barrier (BBB) is a highly regulated physical and functional boundary that
tightly controls the transport of materials between the blood and the brain. There is an …

Abstract Background Coronaviruses such as Severe Acute Respiratory Syndrome
coronavirus (SARS), Middle Eastern Respiratory Syndrome (MERS) and Severe Acute …

In vitro models of the human blood–brain barrier (BBB) are increasingly used to develop
therapeutics that can cross the BBB for treating diseases of the central nervous system. Here …

A few protein kinases and phosphatases regulate tau protein phosphorylation and an
imbalance in their enzyme activity results in tau hyper-phosphorylation. Aberrant tau …

Neurodegenerative diseases (NDDs) significantly contribute to morbidity and mortality
worldwide. The suboptimal effect of currently used therapeutic approaches administered via …

The need to understand human body functions, monitor disease progression, and advance
in drug development have consistently been major driving forces for medical innovations …

Many drugs currently used in clinics to treat different diseases show low solubilities in
aqueous solutions and must be then administered with the aid of organic solvents within the …

We lack the fundamental information needed to understand how DNA damage in the brain is
generated and how it is controlled over a lifetime in the absence of replication check points …

Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has
devastating effects on individuals, often resulting in dementia. AD is primarily defined by the …

Neurodegeneration is characterized by progressive neuronal loss in the brain impairing
normal brain functioning. Cognitive and motor deficits are common symptoms of …