Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Protein ADP-ribosylation is essential for the regulation of several cellular pathways,
enabling dynamic responses to diverse pathophysiological conditions. It is modulated …

Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) form clinically and
genetically heterogeneous malignancies, characterized by distinct prognoses based upon …

ADP-ribosylation is an intricate and versatile posttranslational modification involved in the
regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives …

Metastatic progression of colorectal adenocarcinoma (CRC) remains poorly understood and
poses significant challenges for treatment. To overcome these challenges, we performed …

Background Cervical cancer (CC) remains a leading cause of gynaecological cancer-
related mortality with infection by human papilloma virus (HPV) being the most important risk …

Genetic factors undoubtedly affect the development of congenital heart disease (CHD) but
still remain ill defined. We sought to identify genetic risk factors associated with CHD and to …

Background In cancer research, high-throughput screening technologies produce large
amounts of multiomics data from different populations and cell types. However, analysis of …

Alternative splicing (AS) has emerged as a key event in tumor development and
microenvironment formation. However, comprehensive analysis of AS and its clinical …

ADP-ribosylation (ADPr) is a reversible post-translational modification of proteins, which
controls major cellular and biological processes, including DNA damage repair, cell …