Transcription regulation networks control the expression of genes. The transcription
networks of well-studied microorganisms appear to be made up of a small set of recurring …

The interaction of bacteria with surfaces has important implications in a range of areas,
including bioenergy, biofouling, biofilm formation, and the infection of plants and animals …

We introduce BacDrop, a highly scalable technology for bacterial single-cell RNA
sequencing that has overcome many challenges hindering the development of scRNA-seq …

Experience and memory of environmental stimuli that indicate future stress can prepare
(prime) organismic stress responses even in species lacking a nervous system. The process …

Bacteria induce stress responses that protect the cell from lethal factors such as DNA-
damaging agents. Bacterial populations also form persisters, dormant cells that are highly …

Persisters are a subpopulation of antibiotic-tolerant cells responsible for the recalcitrance of
chronic infections. Our current understanding of persister formation is primarily based on …

Evolutionary novelties have been important in the history of life, but their origins are usually
difficult to examine in detail. We previously described the evolution of a novel trait, aerobic …

Beyond fuelling cellular activities with building blocks and energy, metabolism also
integrates environmental conditions into intracellular signals. The underlying regulatory …

Biological systems that perform multiple tasks face a fundamental trade-off: A given
phenotype cannot be optimal at all tasks. Here we ask how trade-offs affect the range of …

Microscopy image analysis is a major bottleneck in quantification of single-cell microscopy
data, typically requiring human oversight and curation, which limit both accuracy and …