Chronic pain constitutes an abnormal pain state that detrimentally affects the quality of life,
daily activities, occupational performance, and stability of mood. Despite the prevalence of …

Neuropathic pain is a chronic and debilitating condition characterised by episodes of
hyperalgesia and allodynia. It occurs following nerve damage from disease, inflammation or …

Background Growing evidence shows that C-Type Lectin Domain Containing 7A (Clec7a)
may be involved into neuroinflammatory injury of various neurological diseases. However …

In this study, we recruited 50 chronic pain (neuropathic and nociceptive) and 43 pain-free
controls to identify specific blood biomarkers of chronic neuropathic pain (CNP). Affymetrix …

Background Pro-resolving mediators (PRMs) are considered as emerging analgesics for
chronic pain. Maresin 1 (MaR1) is a newly identified member of PRMs, and recent studies …

Despite significant advances in our understanding of the molecular basis of pain, the precise
contributions of individual genes to our perception of this primal sensation remains …

Background Chronic neuropathic pain (CNP) is a debilitating condition, often refractory to
currently available drugs. Understanding biochemical alterations in peripheral tissues such …

Abstract The Biospecimen Collection and Processing Working Group of the National
Institutes of Health (NIH) HEAL Initiative BACPAC Research Program was charged with …

Abstract Dipeptidyl peptidase III (DPP III) is a cytosolic, two-domain zinc-exopeptidase. It is
widely distributed in mammalian tissues, where it's involved in the final steps of normal …

Background The reactivity enhancement of pain sensitive neurons in the nervous system is
a feature of the pathogenesis for neuropathic pain (NP), yet the underlying mechanisms …