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Bacteriophage T4 head: structure, assembly, and genome packaging
Bacteriophage (phage) T4 has served as an extraordinary model to elucidate biological
structures and mechanisms. Recent discoveries on the T4 head (capsid) structure, portal …
structures and mechanisms. Recent discoveries on the T4 head (capsid) structure, portal …
[HTML][HTML] The mechano-chemistry of a viral genome packaging motor
Highlights•Single molecule, structural and computational studies on viral dsDNA packaging
motors have illuminated the underlying mechano-chemistry of genome packaging by dsDNA …
motors have illuminated the underlying mechano-chemistry of genome packaging by dsDNA …
Design of bacteriophage T4-based artificial viral vectors for human genome remodeling
Designing artificial viral vectors (AVVs) programmed with biomolecules that can enter
human cells and carry out molecular repairs will have broad applications. Here, we describe …
human cells and carry out molecular repairs will have broad applications. Here, we describe …
Insights into a viral motor: the structure of the HK97 packaging termination assembly
Double-stranded DNA viruses utilise machinery, made of terminase proteins, to package
viral DNA into the capsid. For cos bacteriophage, a defined signal, recognised by small …
viral DNA into the capsid. For cos bacteriophage, a defined signal, recognised by small …
[HTML][HTML] Viral small terminase: A divergent structural framework for a conserved biological function
The genome packaging motor of bacteriophages and herpesviruses is built by two
terminase subunits, known as large (TerL) and small (TerS), both essential for viral genome …
terminase subunits, known as large (TerL) and small (TerS), both essential for viral genome …
Viral genome packaging machines: Structure and enzymology
Although the process of genome encapsidation is highly conserved in tailed bacteriophages
and eukaryotic double-stranded DNA viruses, there are two distinct packaging pathways that …
and eukaryotic double-stranded DNA viruses, there are two distinct packaging pathways that …
The beauty of bacteriophage T4 research: lindsay W. black and the T4 head assembly
A Kuhn, JA Thomas - Viruses, 2022 - mdpi.com
Viruses are biochemically complex structures and mainly consist of folded proteins that
contain nucleic acids. Bacteriophage T4 is one of most prominent examples, having a tail …
contain nucleic acids. Bacteriophage T4 is one of most prominent examples, having a tail …
Revolving hexameric ATPases as asymmetric motors to translocate double-stranded DNA genome along one strand
DsDNA translocation through nanoscale pores is generally accomplished by ATPase
biomotors. The discovery of the revolving dsDNA translocation mechanism, as opposed to …
biomotors. The discovery of the revolving dsDNA translocation mechanism, as opposed to …
Mechanism of Viral DNA Packaging in Phage T4 Using Single-Molecule Fluorescence Approaches
In all tailed phages, the packaging of the double-stranded genome into the head by a
terminase motor complex is an essential step in virion formation. Despite extensive …
terminase motor complex is an essential step in virion formation. Despite extensive …
[HTML][HTML] The M13 phage assembly machine has a membrane-spanning oligomeric ring structure
M Haase, L Tessmer, L Köhnlechner, A Kuhn - Viruses, 2022 - mdpi.com
Bacteriophage M13 assembles its progeny particles in the inner membrane of the host. The
major component of the assembly machine is G1p and together with G11p it generates an …
major component of the assembly machine is G1p and together with G11p it generates an …