Efavirenz and the CNS: what we already know and questions that need to be answered

N Apostolova, HA Funes, A Blas-Garcia… - Journal of …, 2015 - academic.oup.com
The NNRTI efavirenz has long been one of the most frequently employed antiretroviral drugs
in the multidrug regimens used to treat HIV infection, in accordance with its well …

Mechanisms of action and persistent neuroplasticity by drugs of abuse

ER Korpi, B den Hollander, U Farooq… - Pharmacological …, 2015 - Elsevier
Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Efavirenz: history, development and future

B Costa, N Vale - Biomolecules, 2022 - mdpi.com
Efavirenz (Sustiva®) is a first-generation non-nucleoside reverse transcriptase inhibitor
(NNRTI) used to treat human immunodeficiency virus (HIV) type 1 infection or to prevent the …

Mental health of quarantine and isolation

D Huremović - Psychiatry of pandemics: A mental health response to …, 2019 - Springer
Isolating exposed individuals from the unexposed ones is a crucial measure in breaking up
a chain of infection. All forms of separation and isolation, however, tend to impose an …

Adverse neuropsychiatric events and recreational use of efavirenz and other HIV-1 antiretroviral drugs

DA Dalwadi, L Ozuna, BH Harvey, M Viljoen… - Pharmacological …, 2018 - Elsevier
Efavirenz is a highly effective HIV-1 antiretroviral; however, it is also frequently associated
with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep …

[HTML][HTML] HIV-associated apathy/depression and neurocognitive impairments reflect persistent dopamine deficits

KA McLaurin, M Harris, V Madormo, SB Harrod… - Cells, 2021 - mdpi.com
Individuals living with human immunodeficiency virus type 1 (HIV-1) are often plagued by
debilitating neurocognitive impairments and affective alterations; the pathophysiology …

Neuropsychiatric effects of HIV antiviral medications

GJ Treisman, O Soudry - Drug safety, 2016 - Springer
The development of antiretroviral therapy (ART) has dramatically increased the lifespan of
HIV patients but treatment is complicated by numerous adverse effects and toxicities. ART …

Evaluating neurodevelopmental consequences of perinatal exposure to antiretroviral drugs: current challenges and new approaches

JG Schnoll, B Temsamrit, D Zhang, H Song… - Journal of Neuroimmune …, 2021 - Springer
As antiretroviral therapy (ART) becomes increasingly affordable and accessible to women of
childbearing age across the globe, the number of children who are exposed to Human …

Whoonga: Potential Recreational Use of HIV Antiretroviral Medication in South Africa

DJ Grelotti, EF Closson, JA Smit, Z Mabude… - AIDS and Behavior, 2014 - Springer
Whoonga is a drug cocktail in South Africa rumored to contain illicit drugs and HIV
antiretroviral (ARV) medication. Although its use may adversely impact adherence to HIV …

HIV neuropathogenesis in the presence of a disrupted dopamine system

EA Nickoloff-Bybel, TM Calderon, PJ Gaskill… - Journal of Neuroimmune …, 2020 - Springer
Antiretroviral therapy (ART) has transformed HIV into a chronic condition, lengthening and
improving the lives of individuals living with this virus. Despite successful suppression of HIV …