Small heat shock proteins (sHsps) are conserved across species and are important in stress
tolerance. Many sHsps exhibit chaperone-like activity in preventing aggregation of target …

The proteostasis network (PN) regulates protein synthesis, folding, transport, and
degradation to maintain proteome integrity and limit the accumulation of protein aggregates …

Hsp27 and αB-crystallin are molecular chaperones that are constitutively expressed in
several mammalian cells, particularly in pathological conditions. These proteins share …

The sarcomere is the basic contractile unit of striated muscle and is a highly ordered protein
complex with the actin and myosin filaments at its core. Assembling the sarcomere …

Argyrophilic grain disease (AGD) is a common sporadic neurodegenerative disease of old
age characterized by the presence of argyrophilic grains (AGs)—dendritic-derived …

Small heat shock proteins (sHsps) regulate a large number of fundamental cellular
processes and are involved in many pathological diseases. They share complex …

Neural stem and progenitor cells (NSPCs) are critical for continued cellular replacement in
the adult brain. Lifelong maintenance of a functional NSPC pool necessitates stringent …

The cytoskeleton is a highly complex network of three major intracellular filaments,
microfilaments (MFs), microtubules (MTs) and intermediate filaments (IFs). This network …

The ability of cells to respond to stress is central to health. Stress can damage folded
proteins, which are vulnerable to even minor changes in cellular conditions. To maintain …

Cells have evolved multiple and sophisticated stress response mechanisms aiming to
prevent macromolecular (including proteins, lipids, and nucleic acids) damage and to …