Genomic frontiers in congenital heart disease
The application of next-generation sequencing to study congenital heart disease (CHD) is
increasingly providing new insights into the causes and mechanisms of this prevalent birth …
increasingly providing new insights into the causes and mechanisms of this prevalent birth …
Lifespan Perspective on Congenital Heart Disease Research: JACC State-of-the-Art Review
More than 90% of patients with congenital heart disease (CHD) are nowadays surviving to
adulthood and adults account for over two-thirds of the contemporary CHD population in …
adulthood and adults account for over two-thirds of the contemporary CHD population in …
[HTML][HTML] Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease
To define the multi-cellular epigenomic and transcriptional landscape of cardiac cellular
development, we generated single-cell chromatin accessibility maps of human fetal heart …
development, we generated single-cell chromatin accessibility maps of human fetal heart …
KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis
JR Raymundo, H Zhang, G Smaldone… - The Journal of …, 2024 - Am Soc Clin Investig
Aplasia cutis congenita (ACC) is a congenital epidermal defect of the midline scalp and has
been proposed to be due to a primary keratinocyte abnormality. Why it forms mainly at this …
been proposed to be due to a primary keratinocyte abnormality. Why it forms mainly at this …
The heart is a resident tissue for hematopoietic stem and progenitor cells in zebrafish
D Bornhorst, AV Hejjaji, L Steuter… - Nature …, 2024 - nature.com
The contribution of endocardial cells (EdCs) to the hematopoietic lineages has been
strongly debated. Here, we provide evidence that in zebrafish, the endocardium gives rise to …
strongly debated. Here, we provide evidence that in zebrafish, the endocardium gives rise to …
[HTML][HTML] BMP10 signaling promotes the development of endocardial cells from human pluripotent stem cell-derived cardiovascular progenitors
The embryonic endocardium is essential for early heart development as it functions to
induce trabecular myocardium, the first heart tissue to form, and is the source of the cells that …
induce trabecular myocardium, the first heart tissue to form, and is the source of the cells that …
Spatially organized cellular communities form the develo** human heart
The heart, which is the first organ to develop, is highly dependent on its form to function,.
However, how diverse cardiac cell types spatially coordinate to create the complex …
However, how diverse cardiac cell types spatially coordinate to create the complex …
Computational profiling of hiPSC-derived heart organoids reveals chamber defects associated with NKX2-5 deficiency
Heart organoids have the potential to generate primary heart-like anatomical structures and
hold great promise as in vitro models for cardiac disease. However, their properties have not …
hold great promise as in vitro models for cardiac disease. However, their properties have not …
[HTML][HTML] Genetics of congenital heart disease: a narrative review of recent advances and clinical implications
Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …
leading cause of mortality in childhood. Although advances in clinical management have …
Human stem cells for cardiac disease modeling and preclinical and clinical applications—are we on the road to success?
CD Correia, A Ferreira, MT Fernandes, BM Silva… - Cells, 2023 - mdpi.com
Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO)
as the leading cause of death, contributing to a significant and growing global health and …
as the leading cause of death, contributing to a significant and growing global health and …