Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

H Zhang, X Yue, Z Chen, C Liu, W Wu, N Zhang, Z Liu… - Molecular Cancer, 2023 - Springer
Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

Exosomes and cancer-Diagnostic and prognostic biomarkers and therapeutic vehicle

X Wang, L Tian, J Lu, IOL Ng - Oncogenesis, 2022 - nature.com
Exosomes belong to a subpopulation of extracellular vesicles secreted by the dynamic
multistep endocytosis process and carry diverse functional molecular cargoes, including …

mRNA-based vaccines and therapeutics for COVID-19 and future pandemics

VP Chavda, S Soni, LK Vora, S Soni, A Khadela… - Vaccines, 2022 - mdpi.com
An unheard mobilization of resources to find SARS-CoV-2 vaccines and therapies has been
sparked by the COVID-19 pandemic. Two years ago, COVID-19's launch propelled mRNA …

Exosome for mRNA delivery: strategies and therapeutic applications

Z Iqbal, K Rehman, A Mahmood, M Shabbir… - Journal of …, 2024 - Springer
Messenger RNA (mRNA) has emerged as a promising therapeutic molecule with numerous
clinical applications in treating central nervous system disorders, tumors, COVID-19, and …

Antitumor applications of photothermal agents and photothermal synergistic therapies

C Li, Y Cheng, D Li, Q An, W Zhang, Y Zhang… - International Journal of …, 2022 - mdpi.com
As a new tumor treatment strategy, photothermal therapy (PTT) has the advantages of
accuracy, ease of administration, a high efficiency and low side effects. Photothermal …

tRNA therapeutics for genetic diseases

J Coller, Z Ignatova - Nature Reviews Drug Discovery, 2024 - nature.com
Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their
therapeutic potential for the treatment of genetic diseases—primarily those associated with a …

Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy

KKW To, Z Huang, H Zhang, CR Ashby Jr, L Fu - Drug Resistance Updates, 2024 - Elsevier
Multidrug resistance (MDR) is one of the primary factors that produces treatment failure in
patients receiving cancer chemotherapy. MDR is a complex multifactorial phenomenon …

Tumor-targeted exosomes for delivery of anticancer drugs

R Raguraman, D Bhavsar, D Kim, X Ren, V Sikavitsas… - Cancer letters, 2023 - Elsevier
Exosomes are small phospholipid bilayer vesicles that are naturally produced by all living
cells, both prokaryotes and eukaryotes. The exosomes due to their unique size, reduced …

Advances in lipid-based carriers for cancer therapeutics: Liposomes, exosomes and hybrid exosomes

DN Moholkar, R Kandimalla, RC Gupta, F Aqil - Cancer Letters, 2023 - Elsevier
Cancer has recently surpassed heart disease as the leading cause of deaths worldwide for
the age group 45–65 and has been the primary focus for biomedical researchers. Presently …

Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application

Q Yang, S Li, H Ou, Y Zhang, G Zhu, S Li… - Journal of …, 2024 - Springer
Malignancy is a major public health problem and among the leading lethal diseases
worldwide. Although the current tumor treatment methods have therapeutic effect to a certain …