Organic syntheses are composed of two main types of reactions: Carbon-carbon bond
formations and functional group transformations. CC bond formation is the essence of …

During the last century, organometallic reagents prepared from main group metals, 1 such
as organolithium, organomagnesium, and organozinc compounds, have played a central …

There are still some synthetic chemists who hesitate to use metal-mediated or-catalysed
reactions. The Pauson–Khand reaction (PKR) is a powerful transformation that has now …

Organosilicon reagents are highly versatile and privileged scaffolds in modern synthetic
chemistry, largely due to the range of transformations the groups are amenable to. The β …

Conclusions The first part of this review clearly demonstrates the diversity and power of
asymmetric domino reactions based on the use of chiral auxiliaries in the field of synthetic …

Since the advent of penicillin, the β-lactam antibiotics have been the subject of much
discussion and investigation, within both the scientific and public sectors. The primary …

Tandem reactions that proceed with a single metal catalyst precursor offer novel
opportunities for develo** efficient new reaction sequences. In this regard, reaction …

The Pd-catalysed formation of a C–O bond from allenes mainly occurs via the inter-or
intramolecular reaction with a hydroxyl group belonging to an alcohol, a phenol or an acid. A …

The [2+ 2+ 1] cyclization of an alkyne, an alkene and carbon monoxide, ie, the Pauson–
Khand reaction, is one of the most powerful tools for constructing a five-membered ring. In …

The synthesis of cyclopentenones is most frequently achieved via an organometallic
approach. The widely studied route, the Pauson–Khand reaction (PKR), incorporates three …