Amyotrophic lateral sclerosis pathoetiology and pathophysiology: roles of astrocytes, gut microbiome, and muscle interactions via the mitochondrial melatonergic …
The pathoetiology and pathophysiology of motor neuron loss in amyotrophic lateral sclerosis
(ALS) are still to be determined, with only a small percentage of ALS patients having a …
(ALS) are still to be determined, with only a small percentage of ALS patients having a …
Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics
Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …
Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation
Effective drugs for atrial fibrillation (AF) are lacking, resulting in significant morbidity and
mortality. This study demonstrates that network proximity analysis of differentially expressed …
mortality. This study demonstrates that network proximity analysis of differentially expressed …
Current drug repurposing strategies for rare neurodegenerative disorders
S Shah, MM Dooms, S Amaral-Garcia… - Frontiers in …, 2021 - frontiersin.org
Rare diseases are life-threatening or chronically debilitating low-prevalent disorders caused
by pathogenic mutations or particular environmental insults. Due to their high complexity …
by pathogenic mutations or particular environmental insults. Due to their high complexity …
Current insights in the molecular genetic pathogenesis of amyotrophic lateral sclerosis
W Zhou, R Xu - Frontiers in Neuroscience, 2023 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease
that leads to the massive loss of motor neurons in cerebrum, brain stem and spinal cord. It …
that leads to the massive loss of motor neurons in cerebrum, brain stem and spinal cord. It …
[HTML][HTML] Impact of the renin-angiotensin system on the pathogeny and pharmacotherapeutics of neurodegenerative diseases
Brain neurodegenerative diseases (BND) are debilitating conditions that are especially
characteristic of a certain period of life and considered major threats to human health …
characteristic of a certain period of life and considered major threats to human health …
The landscape of the methodology in drug repurposing using human genomic data: a systematic review
The process of drug development is expensive and time-consuming. In contrast, drug
repurposing can be introduced to clinical practice more quickly and at a reduced cost. Over …
repurposing can be introduced to clinical practice more quickly and at a reduced cost. Over …
Network medicine informed multiomics integration identifies drug targets and repurposable medicines for Amyotrophic Lateral Sclerosis
Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating, immensely complex
neurodegenerative disease by lack of effective treatments. We developed a network …
neurodegenerative disease by lack of effective treatments. We developed a network …
[HTML][HTML] In silico drug repurposing in COVID-19: A network-based analysis
The SARS-CoV-2 pandemic is a worldwide public health emergency. Despite the beginning
of a vaccination campaign, the search for new drugs to appropriately treat COVID-19 …
of a vaccination campaign, the search for new drugs to appropriately treat COVID-19 …
Integrating transcriptomic and structural insights: revealing drug repurposing opportunities for sporadic ALS
Amyotrophic lateral sclerosis (ALS) is a progressive and devastating neurodegenerative
disorder characterized by the loss of upper and lower motor neurons, resulting in debilitating …
disorder characterized by the loss of upper and lower motor neurons, resulting in debilitating …