Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

Malaria, which is caused by Plasmodium spp., starts with an asymptomatic phase, during
which sporozoites, the parasite form that is injected into the skin by a mosquito, develop into …

Background Additional interventions are needed to reduce the morbidity and mortality
caused by malaria. Methods We conducted a two-part, phase 1 clinical trial to assess the …

Glycosylation processes are under high natural selection pressure, presumably because
these can modulate resistance to infection. Here, we asked whether inactivation of the UDP …

This pocket-sized resource offers rapid, portable access to the most important facts and
concepts from Robbins and Cotran Pathologic Basis of Disease, 7th Edition. It is a superb …

Plasmodium sporozoites make a remarkable journey from the mosquito midgut to the
mammalian liver. The sporozoite's major surface protein, circumsporozoite protein (CSP), is …

Many protozoans of the phylum Apicomplexa are invasive parasites that exhibit a substrate-
dependent gliding motility. Plasmodium (malaria) sporozoites, the stage of the parasite that …

The gene for the circumsporozoite (CS) protein of Plasmodium falciparum has been cloned
and its nucleotide sequence determined. The gene encodes a protein of 412 amino acids as …

Grammar is a science that is more than 2000 years old, whereas immunology has become a
respectable part of biology only during the past hundred years. Though both sciences still …

A family of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s)
was identified in malaria parasites. This family includes sequence-specific transcription …