The Hippo-Yes-associated protein (YAP) signaling network plays a central role as an
integrator of signals that control cellular proliferation and differentiation. The past several …

Understanding the mechanisms underlying evasive resistance in cancer is an unmet
medical need to improve the efficacy of current therapies. In this study, a combination of …

Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic
material is transported to lysosomes for degradation and recovery through autophagy. This …

Sorafenib, a first-line drug for advanced hepatocellular carcinoma (HCC), shows a favorable
anti-tumor effect while resistance is a barrier impeding patients from benefiting from it. Thus …

Background Due to the hypoxia and nutrient deficiency microenvironment, glioblastoma
(GBM) exhibits high autophagy activity and autophagy plays an important role in the …

Filovirus-host interactions play important roles in all stages of the virus lifecycle. Here, we
identify LATS1/2 kinases and YAP, key components of the Hippo pathway, as critical …

Understanding the mechanisms underlying evasive resistance in cancer is an unmet
medical need to improve the efficacy of current therapies. In hepatocellular carcinoma …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality
worldwide. Sorafenib is the first multi-tyrosine kinase inhibitor approved for HCC and it has …

Collagen membranes produced in vitro with different degrees of intrafibrillar mineralization
are potentially useful for guided bone regeneration (GBR). However, highly-mineralized …

Hepatocellular carcinoma (HCC) is a highly lethal malignancy characterized by poor
prognosis and a low 5-year survival rate. Drug treatment is proving to be effective in anti …