Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism—
circadian rhythmicity—to anticipate the daily changes caused by this rotation. The molecular …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

The cell cycle and the circadian clock operate as biological oscillators whose timed
functions are tightly regulated. Accumulating evidence illustrates the presence of molecular …

The circadian clock is an evolutionarily conserved timekeeper that adapts body physiology
to diurnal cycles of around 24 h by influencing a wide variety of processes such as sleep‐to …

Biology is dynamic. Timescales range from frenetic sub-second ion fluxes and enzymatic
reactions to the glacial millions of years of evolutionary change. Falling somewhere in the …

Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity
to self-renew while remaining poised to differentiate into multiple progenies in the context of …

The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of
time for the organism. The synchrony between the daily challenges imposed by the …

Links between oncogenic drivers and cancer cell metabolism have emerged over the past
several decades, indicating that constitutive oncogenic growth signaling can render cancers …

Obesity is a chronic and relapsing public health problem with an extensive list of associated
comorbidities. The worldwide prevalence of obesity has nearly tripled over the last five …