[HTML][HTML] The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2

L Bauer, BM Laksono, FMS de Vrij, SA Kushner… - Trends in …, 2022 - cell.com
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with
a diverse spectrum of neurological complications during the acute and postacute stages …

Neurological complications and infection mechanism of SARS-COV-2

D Wan, T Du, W Hong, L Chen, H Que, S Lu… - Signal Transduction and …, 2021 - nature.com
Abstract Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives.
Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS …

Neuroinvasion of SARS-CoV-2 in human and mouse brain

E Song, C Zhang, B Israelow, A Lu-Culligan… - Journal of Experimental …, 2021 - rupress.org
Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects
multiple organ systems including the central nervous system (CNS). Yet, there is no …

The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice

EM Rhea, AF Logsdon, KM Hansen, LM Williams… - Nature …, 2021 - nature.com
It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes
coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome …

[HTML][HTML] Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens

RM Karvas, SA Khan, S Verma, Y Yin, D Kulkarni… - Cell Stem Cell, 2022 - cell.com
Trophoblast organoids derived from placental villi provide a 3D model system of human
placental development, but access to first-trimester tissues is limited. Here, we report that …

Post-infection cognitive impairments in a cohort of elderly patients with COVID-19

YH Liu, YR Wang, QH Wang, Y Chen, X Chen… - Molecular …, 2021 - Springer
Background Understanding the long-term effects of coronavirus disease 2019 (COVID-19)
on cognitive function is essential for monitoring the cognitive decline in the elderly …

ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response

C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen… - Cell stem cell, 2021 - cell.com
ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …

Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system

P Wang, L **, M Zhang, Y Wu, Z Duan, Y Guo… - Nature Biomedical …, 2024 - nature.com
In some patients, COVID-19 can trigger neurological symptoms with unclear pathogenesis.
Here we describe a microphysiological system integrating alveolus and blood–brain barrier …

Animal and translational models of SARS-CoV-2 infection and COVID-19

MD Johansen, A Irving, X Montagutelli, MD Tate… - Mucosal …, 2020 - nature.com
COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The …

Tunneling nanotubes provide a route for SARS-CoV-2 spreading

A Pepe, S Pietropaoli, M Vos, G Barba-Spaeth… - Science …, 2022 - science.org
Neurological manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection represent a major issue in long coronavirus disease. How SARS-CoV-2 …