Food antioxidants: chemical insights at the molecular level

A Galano, G Mazzone, R Alvarez-Diduk… - Annual review of …, 2016 - annualreviews.org
In this review, we briefly summarize the reliability of the density functional theory (DFT)-
based methods to accurately predict the main antioxidant properties and the reaction …

Computational strategies for predicting free radical scavengers' protection against oxidative stress: where are we and what might follow?

A Galano, J Raúl Alvarez‐Idaboy - International Journal of …, 2019 - Wiley Online Library
Oxidative stress, which is frequently induced by an overproduction of free radicals (FR),
poses a high risk to human health. Thus, finding efficient strategies for scavenging FR is a …

Benchmarking antioxidant-related properties for gallic acid through the use of DFT, MP2, CCSD, and CCSD (T) approaches

GLC de Souza, KA Peterson - The Journal of Physical Chemistry …, 2021 - ACS Publications
We present a benchmark investigation on the O–H bond dissociation enthalpies (BDEs) and
ionization potential (IP) for gallic acid (GA), a widely known polyphenolic antioxidant. These …

Free radicals induced oxidative stress at a molecular level: The current status, challenges and perspectives of computational chemistry based protocols

A Galano - Journal of the Mexican Chemical Society, 2015 - scielo.org.mx
Oxidative stress is frequently caused by an excess of free radicals and has been associated
with a wide variety of health disorders. Therefore, finding strategies for scavenging free …

Gallic acid suppresses inflammation and oxidative stress through modulating Nrf2-HO-1-NF-κB signaling pathways in elastase-induced emphysema in rats

F Sohrabi, M Dianat, M Badavi, M Radan… - … Science and Pollution …, 2021 - Springer
Emphysema is associated with an abnormal airspace enlargement distal to the terminal
bronchioles accompanied by destructive changes in the alveolar walls and chronic …

Phenolic melatonin-related compounds: their role as chemical protectors against oxidative stress

A Galano, R Castañeda-Arriaga, A Pérez-González… - Molecules, 2016 - mdpi.com
There is currently no doubt about the serious threat that oxidative stress (OS) poses to
human health. Therefore, a crucial strategy to maintain a good health status is to identify …

Antioxidant properties comparative study of natural hydroxycinnamic acids and structurally modified derivatives: Computational insights

G Mazzone, N Russo, M Toscano - Computational and Theoretical …, 2016 - Elsevier
Density functional theory (DFT) and time-dependent formulation of DFT (TDDFT) have been
used to explore the antioxidant and absorption properties, respectively of naturally occurring …

Rational Design of Multifunctional Ferulic Acid Derivatives Aimed for Alzheimer's and Parkinson's Diseases

EG Guzmán-López, M Reina, LF Hernández-Ayala… - Antioxidants, 2023 - mdpi.com
Ferulic acid has numerous beneficial effects on human health, which are frequently
attributed to its antioxidant behavior. In this report, many of them are reviewed, and 185 new …

Probing Antioxidant-Related Properties for Phenolic Compounds

IN Soares, KA Peterson… - The Journal of Physical …, 2024 - ACS Publications
In this work, properties related to antioxidant-potential mechanisms (such as the bond
dissociation enthalpy, BDE, for the homolytic cleavage of the O–H bond and ionization …

Theoretical study on the radical scavenging activity of gallic acid

M Molski - Heliyon, 2023 - cell.com
The global descriptors of the chemical activity: ionization potential IP, electron affinity EA,
chemical potential μ, absolute electronegativity χ, molecular hardness η and softness S …