A review of parameter settings for invasive and non-invasive vagus nerve stimulation (VNS) applied in neurological and psychiatric disorders

SL Thompson, GH O'Leary, CW Austelle… - Frontiers in …, 2021 - frontiersin.org
Vagus nerve stimulation (VNS) is an established form of neuromodulation with a long history
of promising applications. Earliest reports of VNS in the literature date to the late 1800's in …

[HTML][HTML] Vagal nerve stimulation for treatment-resistant depression

FR Carreno, A Frazer - Neurotherapeutics, 2017 - Elsevier
Major depressive disorder (MDD) is prevalent. Although standards antidepressants are
more effective than placebo, up to 35% of patients do not respond to 4 or more conventional …

Parametric characterization of neural activity in the locus coeruleus in response to vagus nerve stimulation

DR Hulsey, JR Riley, KW Loerwald… - Experimental …, 2017 - Elsevier
Vagus nerve stimulation (VNS) has emerged as a therapy to treat a wide range of
neurological disorders, including epilepsy, depression, stroke, and tinnitus. Activation of …

[HTML][HTML] How to fail with paired VNS therapy

SA Hays, RL Rennaker II, MP Kilgard - Brain stimulation, 2023 - Elsevier
Vagus nerve stimulation (VNS) has gained enormous traction as a promising bioelectronic
therapy. In particular, the delivery of VNS paired with training to promote neural changes has …

Norepinephrine and serotonin are required for vagus nerve stimulation directed cortical plasticity

DR Hulsey, CM Shedd, SF Sarker, MP Kilgard… - Experimental …, 2019 - Elsevier
Vagus nerve stimulation (VNS) paired with forelimb training drives robust, specific
reorganization of movement representations in the motor cortex. This effect is hypothesized …

Reorganization of motor cortex by vagus nerve stimulation requires cholinergic innervation

DR Hulsey, SA Hays, N Khodaparast, A Ruiz, P Das… - Brain stimulation, 2016 - Elsevier
Background Vagus nerve stimulation (VNS) paired with forelimb training drives robust,
specific reorganization of movement representations in the motor cortex. The mechanisms …

Noise induced hearing loss and tinnitus—new research developments and remaining gaps in disease assessment, treatment, and prevention

TC Wang, TY Chang, R Tyler, YJ Lin, WM Liang… - Brain sciences, 2020 - mdpi.com
Long-term noise exposure often results in noise induced hearing loss (NIHL). Tinnitus, the
generation of phantom sounds, can also result from noise exposure, although …

Application of noninvasive vagal nerve stimulation to stress-related psychiatric disorders

JD Bremner, NZ Gurel, MT Wittbrodt… - Journal of personalized …, 2020 - mdpi.com
Background: Vagal Nerve Stimulation (VNS) has been shown to be efficacious for the
treatment of depression, but to date, VNS devices have required surgical implantation, which …

Non-invasive peripheral nerve stimulation selectively enhances speech category learning in adults

F Llanos, JR McHaney, WL Schuerman, HG Yi… - NPJ science of …, 2020 - nature.com
Adults struggle to learn non-native speech contrasts even after years of exposure. While
laboratory-based training approaches yield learning, the optimal training conditions for …

Cortical map plasticity as a function of vagus nerve stimulation intensity

MS Borland, WA Vrana, NA Moreno, EA Fogarty… - Brain stimulation, 2016 - Elsevier
Background Pairing sensory or motor events with vagus nerve stimulation (VNS) can
reorganize sensory or motor cortex. Repeatedly pairing a tone with a brief period of VNS …