Aims Statin intolerance (SI) represents a significant public health problem for which precise
estimates of prevalence are needed. Statin intolerance remains an important clinical …

Cardiovascular disease is the leading cause of death in women and men globally, with most
due to atherosclerotic cardiovascular disease (ASCVD). Despite progress during the last 30 …

Importance The effects of bempedoic acid on cardiovascular outcomes in statin-intolerant
patients without a prior cardiovascular event (primary prevention) have not been fully …

There is a need to identify high-risk features that predict early-onset atherosclerotic
cardiovascular disease (ASCVD). The authors provide insights to help clinicians identify and …

Importance Optimal health care delivery, both now and in the future, requires a continuous
loop of knowledge generation, dissemination, and uptake on how best to provide care, not …

Background Lipid-lowering therapy with statins and proprotein convertase subtilisin/kexin
type 9 (PCSK9) inhibition are effective strategies in reducing cardiovascular disease risk; …

Background Sex differences in the management of cardiovascular disease have been
reported in secondary care. We conducted a systematic review with meta‐analysis of …

Background: Female patients have historically received less aggressive lipid management
than male patients. Contemporary care patterns and the potential causes for these …

Background Preventive therapy among patients with established atherosclerotic
cardiovascular disease (ASCVD) is generally underused. Whether new guideline …

Importance Despite compelling evidence that statins are safe, are generally well tolerated,
and reduce cardiovascular events, statins are underused even in patients with the highest …