Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …

The development of neoplasia involves a complex and continuous interplay between
malignantly transformed cells and the tumour microenvironment (TME). Cancer …

Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the
adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as …

Emerging evidence indicates that the detection and clearance of cancer cells via
phagocytosis induced by innate immune checkpoints play significant roles in tumor …

Glioblastoma (GBM) is the most aggressive form of primary brain tumor, for which effective
therapies are urgently needed. Cancer cells are capable of evading clearance by …

Background This study aimed to validate whether infusion of GD2-specific fourth-generation
safety-designed chimeric antigen receptor (4SCAR)-T cells is safe and whether CAR-T cells …

Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …

Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-
risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms …

Kupffer cells, the liver tissue resident macrophages, are critical in the detection and
clearance of cancer cells. However, the molecular mechanisms underlying their detection …

Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited
success due to immune evasion mechanisms, coupled with an incomplete understanding of …