Imaging the evolution and pathophysiology of Alzheimer disease
W Jagust - Nature Reviews Neuroscience, 2018 - nature.com
Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …
studies of the relationships between the two major proteins deposited in this disease …
Tau PET imaging in neurodegenerative tauopathies—still a challenge
The accumulation of pathological misfolded tau is a feature common to a collective of
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
Synaptic oligomeric tau in Alzheimer's disease—A potential culprit in the spread of tau pathology through the brain
In Alzheimer's disease, fibrillar tau pathology accumulates and spreads through the brain
and synapses are lost. Evidence from mouse models indicates that tau spreads trans …
and synapses are lost. Evidence from mouse models indicates that tau spreads trans …
Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …
Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease
In Alzheimer's diseases (AD), tau pathology is strongly associated with cognitive decline.
Preclinical evidence suggests that tau spreads across connected neurons in an activity …
Preclinical evidence suggests that tau spreads across connected neurons in an activity …
Synaptic tau seeding precedes tau pathology in human Alzheimer's disease brain
Alzheimer's disease (AD) is defined by the presence of intraneuronal neurofibrillary tangles
(NFTs) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid …
(NFTs) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid …
Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease
In Alzheimer's disease (AD), the Braak staging scheme suggests a stereotypical tau
spreading pattern that does, however, not capture interindividual variability in tau deposition …
spreading pattern that does, however, not capture interindividual variability in tau deposition …
[HTML][HTML] Biomarkers for tau pathology
The aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-
associated tau protein characterizes 80% of all dementia disorders, the most common …
associated tau protein characterizes 80% of all dementia disorders, the most common …
From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy
The term “propagon” is used to define proteins that may transmit misfolding in vitro, in
tissues or in organisms. Among propagons, misfolded tau is thought to be involved in the …
tissues or in organisms. Among propagons, misfolded tau is thought to be involved in the …