Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications

J Cerneckis, H Cai, Y Shi - Signal Transduction and Targeted Therapy, 2024 - nature.com
The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …

[HTML][HTML] AI-enabled organoids: construction, analysis, and application

L Bai, Y Wu, G Li, W Zhang, H Zhang, J Su - Bioactive materials, 2024 - Elsevier
Organoids, miniature and simplified in vitro model systems that mimic the structure and
function of organs, have attracted considerable interest due to their promising applications in …

BANKSY unifies cell ty** and tissue domain segmentation for scalable spatial omics data analysis

V Singhal, N Chou, J Lee, Y Yue, J Liu, WK Chock… - Nature …, 2024 - nature.com
Spatial omics data are clustered to define both cell types and tissue domains. We present
Building Aggregates with a Neighborhood Kernel and Spatial Yardstick (BANKSY), an …

Sulfur fluoride exchange

JA Homer, L Xu, N Kayambu, Q Zheng… - Nature Reviews …, 2023 - nature.com
Click chemistry is a conceptual strategy to rapidly synthesize and discover functional
molecules. Sulfur fluoride exchange (SuFEx) is a click reaction that has revolutionized …

Heterogeneity of hepatocellular carcinoma: from mechanisms to clinical implications

F Safri, R Nguyen, S Zerehpooshnesfchi… - Cancer Gene …, 2024 - nature.com
Hepatocellular Carcinoma (HCC) is one of the most common types of primary liver cancer.
Current treatment options have limited efficacy against this malignancy, primarily owing to …

Generating human bone marrow organoids for disease modeling and drug discovery

AA Olijnik, A Rodriguez-Romera, ZC Wong, Y Shen… - Nature protocols, 2024 - nature.com
The bone marrow supports and regulates hematopoiesis, responding to physiological
requirements for blood cell production over ontogeny and during pathological challenges …

Advanced 3D imaging and organoid bioprinting for biomedical research and therapeutic applications

S Maharjan, C Ma, B Singh, H Kang, G Orive… - Advanced Drug Delivery …, 2024 - Elsevier
Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …

[HTML][HTML] An overview of in vitro 3D models of the blood-brain barrier as a tool to predict the in vivo permeability of nanomedicines

A Pérez-López, AI Torres-Suárez… - Advanced Drug Delivery …, 2023 - Elsevier
The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …

A beginner's guide to cell culture: Practical advice for preventing needless problems

S Weiskirchen, SK Schröder, EM Buhl, R Weiskirchen - Cells, 2023 - mdpi.com
The cultivation of cells in a favorable artificial environment has become a versatile tool in
cellular and molecular biology. Cultured primary cells and continuous cell lines are …

Efficient Therapy of Inflammatory Bowel Disease (IBD) with Highly Specific and Durable Targeted Ta2C Modified with Chondroitin Sulfate (TACS)

X Song, Q Huang, Y Yang, L Ma, W Liu… - Advanced …, 2023 - Wiley Online Library
Non‐invasive localization of lesions and specific targeted therapy are still the main
challenges for inflammatory bowel disease (IBD). Ta, as a medical metal element, has been …