Proteomes are complex—much more so than genomes or transcriptomes. Thus, simplifying
their analysis does not simplify the issue. Proteomes are of proteoforms, not canonical …

Selected reaction monitoring (SRM)–also known as multiple reaction monitoring (MRM)–has
emerged as a promising high‐throughput targeted protein quantification technology for …

Medical diagnostics and treatment has advanced from a one size fits all science to treatment
of the patient as a unique individual. Currently, this is limited solely to genetic analysis …

Multiple reaction monitoring (MRM) mass spectrometry has been successfully applied to
monitor targeted proteins in biological specimens, raising the possibility that assays could …

Tauopathies, including Alzheimer's disease (AD), are associated with the aggregation of
modified microtubule associated protein tau. This pathological state of tau is often referred to …

Objective The pathophysiology of the most common joint disease, osteoarthritis (OA),
remains poorly understood. Since synovial fluid (SF) bathes joint cartilage and synovium, we …

OBJECTIVES: The aim of this study was to develop high-throughput, quantitative and highly
selective mass spectrometric, targeted immunoassays for clinically important proteins in …

Allelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE ε2, ApoE ε3 and ApoE ε4
alleles) gives rise to three protein isoforms (ApoE2, ApoE3 and ApoE4) that differ by 1 or 2 …

Protein biomarker development is a multidisciplinary task involving basic, translational and
clinical research. Integration of multidisciplinary efforts in a single pipeline is challenging …

Serological diagnostics is generally defined as the detection of specific human
immunoglobulins developed against viral, bacterial, or parasitic diseases. Serological tests …