In pharmaceutical research and development, various new chemical entities (NCE) are
found to be poorly water-soluble. Therefore, solubility enhancement, a key factor for higher …

Dedicated the memory of Akademician Valery Vasilievich Lunin, a friend, colleague,
teacher, founder and leader of the research into application of supercritical fluids in …

The interest of the use of supercritical fluids, especially supercritical CO2, for particle
engineering over the last years has received attention from the pharmaceutical industry …

Supercritical antisolvent precipitation (SAS) has been successfully used to micronize several
kinds of materials. A great variety of morphologies, such as nanoparticles with mean …

Many active ingredients currently prescribed show limited therapeutic efficacy, mainly due to
their dissolution rate inadequate to treat the pathology of interest. A large drug particle size …

Nanomedicine consists of the application of nanotechnologies in the medical field. In many
nanomedical applications, supercritical fluids based processes represent the best potential …

Solid multicomponent systems (SMS) are gaining an increasingly important role in the
pharmaceutical industry, to improve the physicochemical properties of active pharmaceutical …

Supercritical antisolvent precipitation (SAS) has been successfully used to produce
microparticles and nanoparticles of controlled size and distribution either as a single …

Abstract p-Toluenesulfonamide (PTS) is a new anticancer drug in development. Its poor
dissolution behavior complicates the design and development of the formulation process …

Supercritical fluid (SCF) technology has been applied to drug product development over the
last thirty years and drug particle generation using SCFs appears to be an efficient way to …