Preventing and managing toxicities of high-dose methotrexate
SC Howard, J McCormick, CH Pui… - The …, 2016 - academic.oup.com
Abstract High-dose methotrexate (HDMTX), defined as a dose higher than 500 mg/m2, is
used to treat a range of adult and childhood cancers. Although HDMTX is safely …
used to treat a range of adult and childhood cancers. Although HDMTX is safely …
Childhood acute lymphoblastic leukemia: progress through collaboration
CH Pui, JJ Yang, SP Hunger, R Pieters… - Journal of Clinical …, 2015 - ascopubs.org
Purpose To review the impact of collaborative studies on advances in the biology and
treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. Methods A …
treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. Methods A …
Acute lymphoblastic leukaemia
H Inaba, M Greaves, CG Mullighan - The Lancet, 2013 - thelancet.com
Acute lymphoblastic leukaemia occurs in both children and adults but its incidence peaks
between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous …
between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous …
Biology, risk stratification, and therapy of pediatric acute leukemias: an update
Purpose We review recent advances in the biologic understanding and treatment of
childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), identify …
childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), identify …
Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia
Purpose Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic
leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk …
leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk …
Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake
M Niemi, MK Pasanen, PJ Neuvonen, M Koulu - Pharmacological reviews, 2011 - Elsevier
The importance of membrane transporters for drug pharmacokinetics has been increasingly
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …
Bringing genome-wide association findings into clinical use
TA Manolio - Nature Reviews Genetics, 2013 - nature.com
Genome-wide association studies (GWASs) have been heralded as a major advance in
biomedical discovery, having identified~ 2,000 robust associations with complex diseases …
biomedical discovery, having identified~ 2,000 robust associations with complex diseases …
Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver
E van de Steeg, V Stránecký… - The Journal of …, 2012 - Am Soc Clin Investig
Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver
into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood …
into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood …
Acute lymphoblastic leukemia
CH Pui, WE Evans - New England Journal of Medicine, 1998 - Mass Medical Soc
Acute lymphoblastic leukemia (ALL) is diagnosed in 3000 to 4000 persons in the United
States each year; two thirds of them are children. 1, 2 The current rate of cure of nearly 80 …
States each year; two thirds of them are children. 1, 2 The current rate of cure of nearly 80 …
Drug transporters in drug efficacy and toxicity
MK DeGorter, CQ **a, JJ Yang… - Annual review of …, 2012 - annualreviews.org
Drug transporters are now widely acknowledged as important determinants governing drug
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …