The GDNF family ligands (GFLs) signal through the canonical signaling receptor Ret and a
glycosyl-phosphatidylinositol-anchored co-receptor, GFRα. In recent years, signaling by …

Decorin, the prototype member of the small leucine‐rich proteoglycans, resides in the tumor
microenvironment and affects the biology of various types of cancer by downregulating the …

Lineage map** has identified both proliferative and quiescent intestinal stem cells, but the
molecular circuitry controlling stem cell quiescence is incompletely understood. By lineage …

Maintenance of adult tissues is carried out by stem cells and is sustained throughout life in a
highly ordered manner,. Homeostasis within the stem-cell compartment is governed by …

No therapy exists to slow down or prevent Parkinson's disease (PD), a debilitating
neurodegenerative disorder. Neurotrophic factors (NTFs) emerged as promising disease …

Precise regulation of the amplitude and duration of receptor tyrosine kinase (RTK) signaling
is critical for the execution of cellular programs and behaviors. Understanding these control …

Slitrks are a family of structurally related transmembrane proteins belonging to the leucine-
rich repeat (LRR) superfamily. Six family members exist (Slitrk1–6) and all are highly …

Signalling by the epidermal growth factor receptor (EGFR) controls morphogenesis and/or
homeostasis of several tissues from worms to mammals. The correct execution of these …

In baseball parlance, a triple threat is a person who can run, hit and throw with aplomb.
Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a cell surface protein …

Abstract The Rearranged during Transfection (RET) oncogene has been extensively
investigated in solid malignancies, particularly thyroid cancer and non-small cell lung cancer …