The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

SJ Hofer, D Carmona‐Gutierrez, MI Mueller… - EMBO Molecular …, 2022 - embopress.org
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

Acyl coenzyme A binding protein (ACBP): An aging‐and disease‐relevant “autophagy checkpoint”

L Montégut, M Abdellatif, O Motiño, F Madeo… - Aging …, 2023 - Wiley Online Library
Acyl coenzyme A binding protein (ACBP), also known as diazepam‐binding inhibitor (DBI),
is a phylogenetically ancient protein present in some eubacteria and the entire eukaryotic …

ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis

O Motiño, F Lambertucci, G Anagnostopoulos… - Proceedings of the …, 2022 - pnas.org
Acyl-coenzyme A (CoA)–binding protein (ACBP), also known as diazepam-binding inhibitor
(DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a …

Inhibition of acyl-CoA binding protein (ACBP) by means of a GABAARγ2-derived peptide

G Anagnostopoulos, E Saavedra, F Lambertucci… - Cell Death & …, 2024 - nature.com
Acyl-CoA binding protein (ACBP) encoded by diazepam binding inhibitor (DBI) is an
extracellular inhibitor of autophagy acting on the gamma-aminobutyric acid A receptor …

Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing's syndrome

H Pan, AL Tian, H Chen, Y **a, A Sauvat… - Nature …, 2024 - nature.com
Cushing's syndrome is caused by an elevation of endogenous or pharmacologically
administered glucocorticoids. Acyl coenzyme A binding protein (ACBP, encoded by the …

Old paradoxes and new opportunities for appetite control in obesity

L Montégut, C Lopez-Otin, C Magnan… - Trends in Endocrinology & …, 2021 - cell.com
Human obesity is accompanied by alterations in the blood concentrations of multiple
circulating appetite regulators. Paradoxically, most of the appetite-inhibitory hormones are …

Palmitic acid impairs human and mouse placental function by inhibiting trophoblast autophagy through induction of acyl-coenzyme A-binding protein (ACBP) …

Y Zhang, LL Ruan, MR Li, L Yao, FF Li… - Human …, 2024 - academic.oup.com
STUDY QUESTION Can exposure to palmitic acid (PA), a common saturated fatty acid,
modulate autophagy in both human and mouse trophoblast cells through the regulation of …

High plasma concentrations of acyl‐coenzyme A binding protein (ACBP) predispose to cardiovascular disease: Evidence for a phylogenetically conserved proaging …

L Montégut, A Joseph, H Chen, M Abdellatif… - Aging …, 2023 - Wiley Online Library
Autophagy defects accelerate aging, while stimulation of autophagy decelerates aging. Acyl‐
coenzyme A binding protein (ACBP), which is encoded by a diazepam‐binding inhibitor …

TSPO protein binding partners in bacteria, animals, and plants

C Hiser, BL Montgomery, S Ferguson-Miller - Journal of Bioenergetics and …, 2021 - Springer
The ancient membrane protein TSPO is phylogenetically widespread from archaea and
bacteria to insects, vertebrates, plants, and fungi. TSPO's primary amino acid sequence is …

[HTML][HTML] The diversity of ACBD proteins–From lipid binding to protein modulators and organelle tethers

M Islinger, JL Costello, S Kors, E Soupene… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Members of the large multigene family of acyl-CoA binding domain containing proteins
(ACBDs) share a conserved motif required for binding of Coenzyme A esterified fatty acids of …