The human history has witnessed the rapid development of technologies such as high-
throughput sequencing and mass spectrometry that led to the concept of “omics” and …

One-quarter of photosynthesis-derived carbon on Earth rapidly cycles through a set of short-
lived seawater metabolites that are generated from the activities of marine phytoplankton …

Mass spectrometry is unmatched in its versatility for studying practically any aspect of the
proteome. Because the foundations of mass spectrometry-based proteomics are complex …

An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …

Chemical modulation of proteins enables a mechanistic understanding of biology and
represents the foundation of most therapeutics. However, despite decades of research, 80 …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

EcoCyc is a bioinformatics database available online at EcoCyc. org that describes the
genome and the biochemical machinery of Escherichia coli K-12 MG1655. The long-term …

Moderate inflammation is essential for standard wound healing. In pathological conditions,
such as diabetes, protracted and refractory wounds are associated with excessive …

The ability of living systems to adapt to changing conditions originates from their capacity to
change their molecular constitution. This is achieved by multiple mechanisms that modulate …