Rubin et al, 1, 2, 3 Emami et al, 4, 5 and Quantitative Analyses of Normal Tissue Effects in
the Clinic (QUANTEC) 6 provided estimates of dose, volume, and outcome data primarily for …

Dose constraints are essential for performing dosimetry, especially for intensity modulation
and for radiotherapy under stereotaxic conditions. We present the update of the …

Purpose This guideline provides updated evidence-based recommendations addressing
recent developments in the management of patients with brain metastases, including …

The use of stereotactic ablative radiotherapy (SABR) in the UK has expanded over the past
decade, in part as the result of several UK clinical trials and a recent NHS England …

Background: The safe use of radiotherapy (RT) requires compliance with dose/volume
constraints (DVCs) for organs at risk (OaRs). However, the available recommendations are …

Background Radiation necrosis (RN) secondary to stereotactic radiosurgery is a significant
cause of morbidity. The optimal management of corticosteroid-refractory brain RN remains …

Background Radiation-induced brain injury (RIBI) is the most serious complication of
radiotherapy in patients with head and neck tumors, which seriously affects the quality of life …

Importance The potential benefit of combining intracranial effective systemic therapy with
radiotherapy for patients with breast cancer with brain metastases remains unclear …

Radiation therapy with stereotactic radiosurgery (SRS) or whole brain radiation therapy is a
mainstay of treatment for patients with brain metastases. The use of SRS in the management …

Purpose Brain metastases are common among adult patients with solid malignancies and
are increasingly being treated with stereotactic radiosurgery (SRS). As more patients with …