Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered
by inflammasomes and executed by gasdermin proteins. The main characteristics of …

T cells are an essential part of the immune system with crucial roles in adaptive response
and the maintenance of tissue homeostasis. Depending on their microenvironment, T cells …

Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease that can
progress to liver fibrosis. Recent clinical advance suggests a reversibility of liver fibrosis, but …

Misfolding and aggregation of disease-specific proteins, resulting in the formation of
filamentous cellular inclusions, is a hallmark of neurodegenerative disease with …

Background Rheumatoid arthritis (RA) is the most common chronic autoimmune connective
tissue disease. However, early RA is difficult to diagnose due to the lack of effective …

Granzymes are a family of serine proteases stored in granules inside cytotoxic cells of the
immune system. Granzyme K (GrK) has been only limitedly characterized and knowledge on …

The biology of human granzymes remains enigmatic in part due to our inability to probe their
functions outside of in vitro assays or animal models with divergent granzyme species. We …

Osteosarcoma is a common malignant bone tumor with a propensity for drug resistance,
recurrence, and metastasis. A growing number of studies have elucidated the dual role of …

Granzymes are a family of small (∼ 32 kDa) serine proteases with a range of substrate
specificities that are stored in, and released from, the cytoplasmic secretory vesicles …

Current strategies for the delivery of proteins into cells face general challenges of
endosomal entrapment and concomitant degradation of protein cargo. Efficient delivery …