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Enhancing microRNA activity through increased endosomal release mediated by nigericin
The therapeutic promise of small-RNA therapeutics is limited, not only by the lack of delivery
vehicles, but also by the inability of the small RNAs to reach intracellular compartments …
vehicles, but also by the inability of the small RNAs to reach intracellular compartments …
Suppression of SIN3A by miR-183 Promotes Breast Cancer Metastasis
ML Davenport, MR Davis, BN Davenport… - Molecular Cancer …, 2022 - aacrjournals.org
Recent work has established that SWI-independent-3 (SIN3) chromatin modification
complexes play key roles in cancer progression. We previously demonstrated that …
complexes play key roles in cancer progression. We previously demonstrated that …
Development of an RNA-based Cancer Therapeutic Restoring Tumor Suppressor microRNA
S Myoung - 2021 - hammer.purdue.edu
Based on the knowledge that miRNAs are dysregulated in diseases such as cancer, there
have been multiple attempts to develop miRNA-based cancer therapeutics. However …
have been multiple attempts to develop miRNA-based cancer therapeutics. However …
Revealing the high propensity of RNAs to non-specifically bind drug-like small molecules
Identifying small molecules that selectively bind a single RNA target while discriminating
against all other cellular RNAs is an important challenge in RNA-targeted drug discovery …
against all other cellular RNAs is an important challenge in RNA-targeted drug discovery …
Enhancing miRNA therapeutic efficacy through combinatorial targeting and vehicle free delivery
EA Orellana - 2018 - search.proquest.com
New alternative therapies to treat cancer have emerged such as the use of small molecules
that target key oncogenic drivers. For instance, clinically relevant tumor suppressive …
that target key oncogenic drivers. For instance, clinically relevant tumor suppressive …