The immunology of sepsis

T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Outcomes after critical illness

MS Herridge, É Azoulay - New England Journal of Medicine, 2023 - Mass Medical Soc
Outcomes after Critical Illness | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American …

SA McClave, BE Taylor, RG Martindale… - JPEN. Journal of …, 2016 - europepmc.org
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically
Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and …

The immunopathology of sepsis and potential therapeutic targets

T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

Sepsis-induced immunosuppression

LK Torres, P Pickkers… - Annual review of …, 2022 - annualreviews.org
Sepsis is expected to have a substantial impact on public health and cost as its prevalence
increases. Factors contributing to increased prevalence include a progressively aging …

Sepsis and septic shock

RS Hotchkiss, LL Moldawer, SM Opal… - Nature reviews Disease …, 2016 - nature.com
For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

The immune system's role in sepsis progression, resolution, and long‐term outcome

MJ Delano, PA Ward - Immunological reviews, 2016 - Wiley Online Library
Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Innate immune responses to trauma

M Huber-Lang, JD Lambris, PA Ward - Nature immunology, 2018 - nature.com
Trauma can affect any individual at any location and at any time over a lifespan. The
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

X Michelet, L Dyck, A Hogan, RM Loftus… - Nature …, 2018 - nature.com
Up to 49% of certain types of cancer are attributed to obesity, and potential mechanisms
include overproduction of hormones, adipokines, and insulin. Cytotoxic immune cells …