Butyrate producers,“The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics

V Singh, GD Lee, HW Son, H Koh, ES Kim… - Frontiers in …, 2023 - frontiersin.org
Gut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological
importance than the other major SCFAs (acetate and propionate). Most butyrate producers …

New approaches and procedures for cancer treatment: Current perspectives

DT Debela, SGY Muzazu, KD Heraro… - SAGE open …, 2021 - journals.sagepub.com
Cancer is a global health problem responsible for one in six deaths worldwide. Treating
cancer has been a highly complex process. Conventional treatment approaches, such as …

Genetic and biological hallmarks of colorectal cancer

J Li, X Ma, D Chakravarti, S Shalapour… - Genes & …, 2021 - genesdev.cshlp.org
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Altered metabolism in cancer: Insights into energy pathways and therapeutic targets

M Tufail, CH Jiang, N Li - Molecular Cancer, 2024 - Springer
Cancer cells undergo significant metabolic reprogramming to support their rapid growth and
survival. This study examines important metabolic pathways like glycolysis, oxidative …

FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms

SK Azzam, H Alsafar, AA Sa**i - International journal of molecular …, 2022 - mdpi.com
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …

Advances in anti-cancer effects and underlying mechanisms of marine algae polysaccharides

W Yao, HM Qiu, KL Cheong, S Zhong - International Journal of Biological …, 2022 - Elsevier
Cancer is a leading cause of death in both develo** and developed countries. With the
increase in the average global life expectancy, it has become a major health problem and …

Copper promotes tumorigenesis by activating the PDK1‐AKT oncogenic pathway in a copper transporter 1 dependent manner

J Guo, J Cheng, N Zheng, X Zhang, X Dai… - Advanced …, 2021 - Wiley Online Library
Copper plays pivotal roles in metabolic homoeostasis, but its potential role in human
tumorigenesis is not well defined. Here, it is revealed that copper activates the …

Nanomaterials for theranostics: recent advances and future challenges

EK Lim, T Kim, S Paik, S Haam, YM Huh… - Nanomaterials and …, 2021 - taylorfrancis.com
The field of nanomedicines has expanded significantly in recent years in the breadth of
compounds under development as well as in the types of technology that are being applied …

Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth

JA Kashatus, A Nascimento, LJ Myers, A Sher… - Molecular cell, 2015 - cell.com
Ras is mutated in up to 30% of cancers, including 90% of pancreatic ductal
adenocarcinomas, causing it to be constitutively GTP-bound, and leading to activation of …

Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness

S Yue, J Li, SY Lee, HJ Lee, T Shao, B Song, L Cheng… - Cell metabolism, 2014 - cell.com
Altered lipid metabolism is increasingly recognized as a signature of cancer cells. Enabled
by label-free Raman spectromicroscopy, we performed quantitative analysis of lipogenesis …