Ras proteins are classical members of small GTPases that function as molecular switches by
alternating between inactive GDP-bound and active GTP-bound states. Ras activation is …

The plasma membrane is a complex, dynamic structure that provides platforms for the
assembly of many signal transduction pathways. These platforms have the capacity to …

Ras proteins occupy dynamic plasma membrane nanodomains called nanoclusters. The
significance of this spatial organization is unknown. Here we show, using in silico and in …

How do Ras isoforms attain oncogenic specificity at the membrane? Oncogenic KRas,
HRas, and NRas (K-Ras, H-Ras, and N-Ras) differentially populate distinct cancers. How …

The identification and characterization of protein interactions is a key topic in current life
science research; a huge variety of methodologies have been established in recent years to …

The molecular mechanisms whereby caveolae exert control over cellular signaling have to
date remained elusive. We have therefore explored the role caveolae play in modulating …

Being praised for the mere fact of enabling the detection of individual fluorophores a dozen
years ago, single-molecule techniques nowadays represent standard methods for the …

Signalling molecules integrate, codify and transport information in cells. Organisation of
these molecules in complexes and clusters improves the efficiency, fidelity and robustness …

Global cellular responses induced by epidermal growth factor (EGF) receptor (EGFR) occur
immediately with a less than 1% occupancy among tens of thousands of EGFR molecules …

RAS oncogenes are among the most commonly mutated proteins in human cancers. They
regulate a wide range of effector pathways that control cell proliferation, survival …