Spirocyclic compounds isolated from plant and animal origins have important applications in
medicinal chemistry. Spiro compounds having cyclic structures fused at a central carbon are …

Polycyclic structures fused at a central carbon are of great interest due to their appealing
conformational features and their structural implications in biological systems. Although …

Several phytochemicals with potential for bioactivity can be found in Polygonum minus (PM).
The goal of this investigation was to establish the minimally toxic dose of PM for …

In the present study, free radical scavenging, cytotoxic, and hemolytic activities of the
polyphenolic compound ethyl gallate isolated from ethanol extract of Acacia nilotica Wild …

N-Vinyl nitrones derived from fluorenone have been prepared via a copper-mediated
coupling between fluorenone oxime and vinyl boronic acids. These compounds undergo …

Objective A new family of 3′-(Mono, di or tri-substituted phenyl)-4′-(4-(methylsulfonyl)
phenyl) spiroisoxazoline derivatives containing indanone spirobridge was designed …

The design of new sp 3 and spiro-enriched fragments has been achieved from 1, 3-dipolar
cycloaddition between alkenes and chloro-oximes. The selection of reagents was performed …

A method is presented for the synthesis of 4-(substituted phenyl)-3-(3-substituted phenyl) 4
H-spiro [isoxazole-5, 3′-pyrido [1, 2-a] pyrimidine]-2′, 4′-dione (3), 3-(4-substituted …

A series of 18-Ar-spirotryprostatin A analogs were synthesized stereoselectively from isatin
via a five-step reaction sequence involving Wittig reaction, 1, 3-dipolar cycloaddition …

In the present work, new isoxazolines were semisynthesized by 1, 3-dipolar cycloaddition
reactions of nitriloxides on (E)-α-atlantone, a sesquiterpene compound isolated from Cedrus …