Objectives We reviewed the existing definitions of psychological frailty and provided a
comprehensive overview of the concept and associated measurements. Study Design and …

Frailty and depression were linked in observational studies, but the causality remains
ambiguous. We intended to explore it using Mendelian randomization (MR). We obtained …

The concept of aging is complex, including many related phenotypes such as healthspan,
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …

1 62.96 31.48 31.94 64.81 31.94 44.44 2 B 2 75.93 72.22 63.89 68.52 66.67 75.00 6 A 3
74.07 81.48 77.08 55.56 72.22 69.44 5 B 4 38.89 33.33 30.56 61.11 41.67 61.11 2 B 5 …

The conceptual change of frailty, from a physical to a biopsychosocial phenotype, expanded
the field of frailty, including social and behavioral domains with critical interaction between …

Frailty is an aging-related clinical phenotype defined as a state in which there is an increase
in a person's vulnerability for dependency and/or mortality when exposed to a stressor …

Background Frailty is a medical syndrome that is strongly associated with mortality risk and
an emerging global health burden. Mental disorders are associated with reduced life …

Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …

Observational studies have shown that the gut microbiome is associated with frailty.
However, whether these associations underlie causal effects remains unknown. Thus, this …

Background Frailty is strongly associated with cardiometabolic diseases in observational
studies. However, whether the observed association reflects causality requires clarification …