Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900 Israel mRNA maturation in
trypanosomes differs from the process in most eukaryotes mainly because protein-coding …

The removal of introns from eukaryotic messenger RNA precursors shares mechanistic
characteristics with the self-splicing of certain introns, prompting speculation that the …

Variable in–frame skip** of exon 9 in cystic fibrosis transmembrane conductance
regulator (CFTR) mRNA transcripts (exon 9−) occurs in the respiratory epithelium. To …

Introns have typically been discovered in an ad hoc fashion: introns are found as a gene is
characterized for other reasons. As complete eukaryotic genome sequences become …

Prior to the chemical steps of mRNA splicing, the extensive base-pairing interaction between
the U4 and U6 spliceosomal snRNAs is disrupted. Here, we use a mutational analysis in …

The branch point (BP) is one of the three obligatory signals required for pre-mRNA splicing.
In mammals, the degeneracy of the motif combined with the lack of a large set of …

U5 snRNA is an essential pre-mRNA splicing factor whose function remains enigmatic.
Specific mutations in a conserved single-stranded loop sequence in yeast U5 snRNA can …

In trypanosomes, the generation of monocistronic mRNAs from polycistronic precursors is
achieved via RNA processing, namely trans-splicing of the spliced leader sequence at the …

During pre-mRNA splicing, a central step in the expression and regulation of eukaryotic
genes, the spliceosome selects splice sites for intron excision and exon ligation. In doing so …

During the early events of pre-mRNA splicing, intronic cis-acting sequences are recognized
and interact through a network of RNA–RNA, RNA–protein, and protein–protein contacts …