When cells are exposed to oxidative stress, DNA damage frequently occurs. The molecular
mechanisms causing this damage may include activation of nucleases and direct reaction of …

In aerobic life, oxidative stress arises from both endogenous and exogenous sources.
Despite antioxidant defence mechanisms, cell damage from oxygen free radicals (OFR) is …

Cellular DNA damage under prooxidant conditions has been shown to be mediated by iron.
In fact, iron is an important element in the establishment of a prooxidant status in the cell. It is …

Oxidants, which are generated by multiple pathways in mammalian organisms, may be
natural carcinogens and contribute to several stages of malignant transformation. Active …

The factors contributing to selective motoneuron loss in amyotrophic lateral sclerosis (ALS)
remain undefined. To investigate whether calcium‐binding proteins contribute to selective …

Exposure of mammalian cells to oxidative stress induced by oxidation‐reduction‐active
quinones and other prooxidants results in depletion of intracellular glutathione, followed by …

Reactive oxygen species (ROS) have been implicated in the pathophysiology of many
neurologic disorders and brain dysfunction. In the same pathological settings evidence has …

There is growing interest in the evaluation of drugs (prescription only medicines and over-
the-counter medicines) as antioxidant prophylactics. Although free radical mechanism in …

Carbonate caves represent subterranean ecosystems that are largely devoid of phototrophic
primary production. In semiarid and arid regions, allochthonous organic carbon inputs …

Oxidant carcinogens interact with multiple cellular targets including membranes, proteins,
and nucleic acids. They cause structural damage to DNA and have the potential to mutate …