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Understanding the physiology of FGF21
FM Fisher, E Maratos-Flier - Annual review of physiology, 2016 - annualreviews.org
Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …
[HTML][HTML] Hepatokines and metabolism: Deciphering communication from the liver
Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …
Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19
The COVID-19 pandemic has been the primary global health issue since its outbreak in
December 2019. Patients with metabolic syndrome suffer from severe complications and a …
December 2019. Patients with metabolic syndrome suffer from severe complications and a …
The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
Summary Fibroblast growth factor 21 (FGF21) is a recently discovered metabolic regulator.
Exogenous FGF21 produces beneficial metabolic effects in animal models; however, the …
Exogenous FGF21 produces beneficial metabolic effects in animal models; however, the …
Fibroblast growth factor 21—metabolic role in mice and men
H Staiger, M Keuper, L Berti… - Endocrine …, 2017 - academic.oup.com
Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …
Adipose tissue in control of metabolism
Diabetes mellitus exerts metabolic stress on cells and it provokes a chronic increase in the
long-term activity of the hypothalamus–pituitary–adrenocortical (HPA) axis, perhaps thereby …
long-term activity of the hypothalamus–pituitary–adrenocortical (HPA) axis, perhaps thereby …
The FGF family: biology, pathophysiology and therapy
The family of fibroblast growth factors (FGFs) regulates a plethora of developmental
processes, including brain patterning, branching morphogenesis and limb development …
processes, including brain patterning, branching morphogenesis and limb development …
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)—
FGF15/19 and FGF21—that can function as hormones. Both FGF15/19 and FGF21 act on …
FGF15/19 and FGF21—that can function as hormones. Both FGF15/19 and FGF21 act on …
Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
J Dushay, PC Chui, GS Gopalakrishnan, M Varela–Rey… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Fibroblast growth factor 21 (FGF21) is an hepatic protein that plays
a critical role in metabolism, stimulating fatty acid oxidation in liver and glucose uptake in fat …
a critical role in metabolism, stimulating fatty acid oxidation in liver and glucose uptake in fat …
The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARα activation in man
C Gälman, T Lundåsen, A Kharitonenkov, HA Bina… - Cell metabolism, 2008 - cell.com
FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated
by PPARα in rodents. However, the physiological role of FGF21 in man is not yet defined …
by PPARα in rodents. However, the physiological role of FGF21 in man is not yet defined …