Cancer is one of the leading causes of death around the world and although the different
clinical approaches have helped to increase survival rates, incidence is still high and so its …

Abstract β-Lapachone (β-lap, 1), an ortho-naphthoquinone natural product isolated from the
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …

Immunogenic cell death (ICD) is a way of reengaging the tumor-specific immune system.
ICD can be induced by treatment with chemotherapeutics. However, only a limited number …

Natural products that contain ortho-quinones show great potential as anticancer agents but
have been largely discarded from clinical development because their redox-cycling …

Posttranslational modification of proteins by ubiquitin (Ub), ie, ubiquitination, mediates a
variety of cellular processes, including protein homeostasis, cell cycle, DNA repair, and viral …

Compounds that exhibit assay interference or undesirable mechanisms of bioactivity are
routinely encountered in assays at various stages of drug discovery. We observed that …

Bioprospecting natural products to find prominent agents for medical application is an area
of scientific endeavor that has produced many clinically used bioactive compounds …

Background The formation of secondary organic aerosols (SOA) by atmospheric oxidation
reactions substantially contributes to the burden of fine particulate matter (PM2. 5), which …

Breast cancer expresses clinically heterogeneous characteristics and requires multipurpose
drug development for curing the different tumor subtypes. Many withanolides have been …

Protein ubiquitination is an important post-translational modification mechanism, which
regulates protein stability and activity. The ubiquitination of proteins can be reversed by …