Over the past decade, circular RNA (circRNA) research has evolved into a bona fide
research field shedding light on the functional consequence of this unique family of RNA …

High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate
vast protein diversity from a limited number of genes. The mechanisms and outcomes of …

The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also
known as nuclear domains or nuclear subcompartments. These self-organizing structures …

Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on
increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against …

Alternative splicing (AS) generates remarkable regulatory and proteomic complexity in
metazoans. However, the functions of most AS events are not known, and programs of …

High-throughput transcriptomic profiling approaches have revealed that alternative splicing
(AS) of precursor mRNAs, a fundamental process by which cells expand their transcriptomic …

Tissue-specific regulatory regions harbor substantial genetic risk for disease. Because brain
development is a critical epoch for neuropsychiatric disease susceptibility, we characterized …

Recent improvements in experimental and computational techniques that are used to study
the transcriptome have enabled an unprecedented view of RNA processing, revealing many …

Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated
during neurodevelopment. However, the precise timing of developmental splicing switches …