Bone fractures and segmental bone defects are a significant source of patient morbidity and
place a staggering economic burden on the healthcare system. The annual cost of treating …

Osteoarthritis (OA) is a common degenerative joint disease characterized by cartilage
degradation, synovitis, subchondral bone sclerosis and osteophyte formation. Current …

Abstract Mesenchymal Stromal Progenitor/Stem Cells (MSCs) are a rare population of non-
hematopoietic stromal cells, present in the bone marrow and most connective tissues of the …

Mesenchymal stromal/stem cells (MSCs) are a population of stromal cells present in the
bone marrow and most connective tissues, capable of differentiation into mesenchymal …

Recent studies suggest that the main driving force behind the therapeutic activity observed
in mesenchymal stem cells (MSCs) are the paracrine factors secreted by these cells. These …

Background Blood vessel formation is fundamental to development, while its dysregulation
can contribute to serious disease. Expectations are that hundreds of millions of individuals …

Purpose The aim of this systematic review is to examine the available clinical evidence in
the literature to support mesenchymal stem cell (MSC) treatment strategies in orthopaedics …

The family of bone morphogenetic proteins (BMPs) comprises approximately 30 secreted
cytokines that signal through transmembrane serine/threonine kinase receptors. The BMP …

Abstract Treatment of extensive bone defects requires autologous bone grafting or
implantation of bone substitute materials. An attractive alternative has been to engineer fully …

Background Cell-based strategies that combine in vitro-expanded autologous chondrocytes
with matrix scaffolds are currently preferred for full-thickness cartilage lesions of the knee≥ …